SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Antiviral efficacy of selective estrogen receptor modulators against SARS-CoV-2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor시험관 내 및 생체 내에서 SARS-CoV-2 감염에 대한 선택적 에스트로겐 수용체 조절제의 항바이러스 효능은 진입 억제제로서 바제독시펜 아세테이트를 나타냅니다Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] Acetate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antiviral efficacy Bazedoxifene bazedoxifene acetate candidate cholesterol cholesterol distribution citrate clinical Clomifene Clomifene citrate contagious coronavirus Coronaviruses Critical delta variant distribution drugs Effect Efficacy endosome acidification Estrogen estrogen receptor evaluated exhibited expression hamster hamsters human cell lines humans identify in vitro in vivo infect Infection information inhibited inhibitor interleukin-6 offer omicron Omicron variant pathogenic variant penetration Postinfection pseudovirus pseudoviruses pulmonary viral reduced reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection selective selective estrogen receptor modulator severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2. Tamoxifen toremifene toremifene citrate variant Vero E6 Vero E6 cell VERO E6 cells weight loss [DOI] 10.1002/jmv.27951 PMC 바로가기 [Article Type] Article
Optimization of Anti-SARS-CoV-2 Treatments Based on Curcumin, Used Alone or Employed as a PhotosensitizerArticle Published on 2022-09-272022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] anti-inflammatory properties Antiviral approach Cell culture cells Concentration COVID-19 Curcuma Curcumin dose effective immunomodulatory in vitro In vitro infection inhibited optimization photodynamic therapy photodynamic therapy. photosensitizer prophylactic treatment reduction reported RNase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication suggested therapy Treatment Vero E6 VERO E6 cells virion virus virus inactivation [DOI] 10.3390/v14102132 PMC 바로가기
Reactogenicity and immunogenicity of the second COVID-19 vaccination in patients with inborn errors of immunity or mannan-binding lectin deficiencyArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activity Adverse reaction analyzed Anti-SARS-CoV-2 S antibody Antibody Response Autoimmune Autoimmune diseases B-lymphocytes Cell Cohort cohort of patient comparable Course COVID-19 COVID-19 vaccination CVID deficiency detect Disease activity dysfunction effective Efficacy and safety Elecsy flow cytometry healthy control humoral humoral immune response Hypogammaglobulinemia IFN-gamma immune system Immunity immunization immunoassay immunodeficiency immunoglobulin replacement therapy in healthy individuals increased risk individual Interferon-gamma lymphocyte neutralization Patient Phenotyping pneumococcal provide reactogenicity receptor Safe SARS-COV-2 infection selective Seven subjects Support syndrome T cell response T-lymphocites the disease triggering underlying disease vaccination vaccination. vaccine response Vero E6 Virus neutralization was performed well X-linked agammaglobulinemia XLA [DOI] 10.3389/fimmu.2022.974987 PMC 바로가기
New Chemicals Suppressing SARS-CoV-2 Replication in Cell CultureArticle Published on 2022-09-052022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] antiviral drug binding calculated candidate Cell Cell culture Chemical Compound coronavirus cytotoxicity database derivatives develop docked docking EC50 value experiment experiments inhibit SARS-CoV-2 inhibitor inhibitors Ligand main protease molecular MPro New protease protein-ligand quantum chemistry. Replication SARS-CoV-2 SARS-CoV-2 replication selected Selection Seven solvent state suppressed Suppressing the SARS-CoV-2 university Vero E6 [DOI] 10.3390/molecules27175732 PMC 바로가기
Anisodamine potently inhibits SARS-CoV-2 infection in vitro and targets its main protease아니소다민은 시험관 내에서 SARS-CoV-2 감염을 강력하게 억제하고 주요 프로테아제를 표적으로 합니다Article Published on 2022-08-062022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acid residue analyzed Anisodamine Antiviral antiviral activity antiviral agent cells Chinese co-cultured coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cys145 disease docking score effective drug effective drugs Gly143 H-bond HEK293 immunofluorescence assay in vitro indicated Infection inhibit M pro main protease molecular docking molecular docking studies Molecular docking study pandemic predicted protease pseudovirus entry reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppressed target the SARS-CoV-2 therapeutic drug Traditional Chinese medicine treating COVID-19 Treatment treatment of COVID-19 Vero E6 VERO E6 cells viral infection Viral infection. [DOI] 10.1016/j.bbrc.2022.05.024 PMC 바로가기 [Article Type] Article
Treatment with metformin glycinate reduces SARS-CoV-2 viral load: An in vitro model and randomized, double-blind, Phase IIb clinical trial메트포르민 글리시네이트로 치료하면 SARS-CoV-2 바이러스 부하 감소: 시험관 내 모델 및 무작위, 이중 맹검, IIb상 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] adaptive aligned Alpha caused Cell Clinical data clinical trial conducted control group coronavirus disease COVID-19 COVID-19 patients COVID-19 treatment dose doses double-blind drug effort Epsilon evaluate exposure to Health Health crisis highlight highlighting identify IIb in vitro in vitro model in vitro result in vitro study in vivo increased survival indicate inhibit metformin Metformin glycinate New coronavirus new coronavirus SARS-CoV-2 new treatment strategy new virus oxygen phase Randomized reduce reduced SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 viral load SARS-CoV-2 viral load. severe disease supplementary oxygen tested the SARS-CoV-2 therapeutic option treated Treatment Treatment effectiveness triggered variant variants of interest Vero E6 VERO E6 cells viral infection Viral load viral replication [DOI] 10.1016/j.biopha.2022.113223 PMC 바로가기 [Article Type] Randomized Controlled Trial
Optimization and evaluation of a live virus SARS-CoV-2 neutralization assay살아있는 바이러스 SARS-CoV-2 중화 분석의 최적화 및 평가Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added antibody application calculated cell monolayer cell suspension cells clinical isolates Coefficient of variance coronavirus correlated correlation Critical described dose ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated functional antibody response functional antibody responses growth immune evasion Immunity include Incubation period infecting Influenza Influenza virus inoculation isolates Live virus microneutralization neutralization Neutralization assay neutralization titers nucleocapsid protein optimization parameter Post-infection Precision protein level reduced replicating virus respiratory SARS-CoV-2 SARS-CoV-2 clinical isolate SARS-CoV-2 clinical isolates SARS-CoV-2 microneutralization assay SARS-CoV-2 neutralization severe acute respiratory syndrome Coronavirus the SARS-CoV-2 the strongest therapeutic Vaccine variance Vero E6 Vero E6 cell VERO E6 cells Viral Viral variants virus virus infection virus inhibition virus inoculum virus neutralization assays Virus titration was determined WHO [DOI] 10.1371/journal.pone.0272298 PMC 바로가기 [Article Type] Article
Development of a Rapid Live SARS-CoV-2 Neutralization Assay Based on a qPCR ReadoutqPCR 판독을 기반으로 한 Rapid Live SARS-CoV-2 중화 분석의 개발Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] antibody Antibody-mediated immunity antiviral activity calculate can be used characteristic controls correlation COVID-19 COVID-19 pandemic cross-neutralization demonstrated detect determine determined by development domain ELISA experiments faster generate gold gold standard Immunity Live virus natural infection neutralization Neutralization assay neutralization assays Neutralizing Neutralizing antibodies neutralizing antibody patient sera priority qPCR qRT-PCR Rapid Receptor-binding domain reduce reduction SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 qRT-PCR Sensitivity and specificity sera significantly standard curve Surrogate neutralization assay. tested vaccination variants Vero E6 Vero E6 cell VERO E6 cells Viral Viral load Viral RNA virus virus isolate Virus neutralization [DOI] 10.1128/jcm.00376-22 PMC 바로가기 [Article Type] Article
A Highly Potent SARS-CoV-2 Blocking Lectin Protein렉틴 단백질을 차단하는 매우 강력한 SARS-CoV-2Article Published on 2022-07-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected blocking cell line coronavirus coronavirus disease Coronavirus disease-19 COVID-19 death Delta demonstrated drug effective entry of SARS-CoV-2 FIVE Frequency globe Hospitalization ICU admissions IFNAR Infection lectin mouse model Mutation New coronavirus omicron Omicron variants pandemic Please add keywords. potent preventing the transmission Prophylactic Protein SARS-CoV-2 secure severe acute respiratory syndrome Coronavirus social contact Spike protein spread of COVID-19 the spike protein variants Vero E6 Wuhan strain [DOI] 10.1021/acsinfecdis.2c00006 PMC 바로가기 [Article Type] Article